China (Mainland)
Phenibut CAS NO.1078-21-3
- Min.Order: 25 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Product Details
Keywords
- Phenibut
- 1078-21-3
- 4-AMINO-3-PHENYLBUTANOIC
Quick Details
- ProName: Phenibut
- CasNo: 1078-21-3
- Molecular Formula: C10H13NO2
- Appearance: White solid
- Application: Used for preparing antidepressants
- DeliveryTime: Spot
- PackAge: Packaging according to actual needs
- Port: any port in China
- ProductionCapacity: 1000 Metric Ton/Year
- Purity: 99%
- Storage: normal temperature
- Transportation: by sea or by air
- LimitNum: 25 Kilogram
Superiority
Melting point: 252.5 ° C (roughestimate)
Boiling point: 311.75 ° C (roughestimate)
Density: 1.1248 (roughestimate)
Refractive index: 1.5710 (estimated)
Solubility: Freebase: 35mg/LinDMSO (195.29mM) at 25 ° C (SellekChem, 2019). Hydrochloridesalt (Cayman, 2016): 25mg/linDMF; 20mg/linDMSO; 14mg/mlinethanol; 10mg/mLinPBS (pH7.2)
Acidity coefficient: (pKa) 4.10 ± 0.10 (Predicted)
Form: solid
Color: White
InchI: InchI=1S/C10H13NO2/c11-7-9 (6-10 (12) 13) 8-4-2-1-3-5-8/h1-5,9H, 6-7,11H2, (H, 12,13)
InchiKey: DAFOCGYVTAOKAJ-UHFFAOYSA-NSMILESCC (O) (=O) CC (C1=CC=CC=C1)
CNCAS database: 1078-21-3 (CASDataBaseReference)
EPA Chemical Substance Information Benzenepropanoicacid,. beta. - (aminomethyl) - (1078-21-3)
The application of 4-amino-3-phenylbutyrate hydrochloride is often used in the preparation of antidepressants and is a very important pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical production processes. Preparation (1): Using benzoyl chloride and ethyl acetoacetate as raw materials, benzoyl ethyl acetate is condensed and hydrolyzed, followed by the condensation of benzaldehyde and nitromethane to produce trans nitrostyrene. The two are then added in a Michel addition reaction, and the addition product is then hydrogenated using Raney nickel catalyst. Finally, it is hydrolyzed in concentrated hydrochloric acid to produce non Nibute. Bioactive Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenycut, PhGABA, β- Phenyl- γ- Aminobutyric acid, β- Phenyl-GABA, as a GABA analogue, is a sedative targeting the central nervous system and has anti anxiety and sedative effects.
Details
Melting point: 252.5 ° C (roughestimate)
Boiling point: 311.75 ° C (roughestimate)
Density: 1.1248 (roughestimate)
Refractive index: 1.5710 (estimated)
Solubility: Freebase: 35mg/LinDMSO (195.29mM) at 25 ° C (SellekChem, 2019). Hydrochloridesalt (Cayman, 2016): 25mg/linDMF; 20mg/linDMSO; 14mg/mlinethanol; 10mg/mLinPBS (pH7.2)
Acidity coefficient: (pKa) 4.10 ± 0.10 (Predicted)
Form: solid
Color: White
InchI: InchI=1S/C10H13NO2/c11-7-9 (6-10 (12) 13) 8-4-2-1-3-5-8/h1-5,9H, 6-7,11H2, (H, 12,13)
InchiKey: DAFOCGYVTAOKAJ-UHFFAOYSA-NSMILESCC (O) (=O) CC (C1=CC=CC=C1)
CNCAS database: 1078-21-3 (CASDataBaseReference)
EPA Chemical Substance Information Benzenepropanoicacid,. beta. - (aminomethyl) - (1078-21-3)
The application of 4-amino-3-phenylbutyrate hydrochloride is often used in the preparation of antidepressants and is a very important pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical production processes. Preparation (1): Using benzoyl chloride and ethyl acetoacetate as raw materials, benzoyl ethyl acetate is condensed and hydrolyzed, followed by the condensation of benzaldehyde and nitromethane to produce trans nitrostyrene. The two are then added in a Michel addition reaction, and the addition product is then hydrogenated using Raney nickel catalyst. Finally, it is hydrolyzed in concentrated hydrochloric acid to produce non Nibute. Bioactive Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenycut, PhGABA, β- Phenyl- γ- Aminobutyric acid, β- Phenyl-GABA, as a GABA analogue, is a sedative targeting the central nervous system and has anti anxiety and sedative effects.